Nouns ending in -aie, -oue, or -eue are feminine.
The whole family: -aie, -oue, -eue. All feminine.
Is roue masculine or feminine?
laroue
The rule behind it
94.4% of -aie / -oue / -eue nouns are feminine
In context
Un monocycle n'a qu'une seule roue.
A unicycle has only one wheel.
On ignore qui inventa en premier la roue.
It's not known who first invented the wheel.
Il y a des roues dans des roues.
There are wheels within wheels.