Nouns ending in -ence are usually feminine, but le silence is masculine.
Silence is one of the rare exceptions: learn it as it is.
Is silence masculine or feminine?
lesilenceexception
The rule behind it
97.6% of -ence nouns are feminine
In context
On fait silence dans la bibliothèque, les garçons.
Be silent in the library, boys.
J'ai interprété son silence comme un refus.
I interpreted her silence as a refusal.
La parole est d’argent, le silence est d’or.
Speech is silver, silence is golden.