Nouns ending in -ence are usually feminine.
The suffix forms abstract nouns, often from verbs.
Is différence masculine or feminine?
ladifférence
The rule behind it
97.6% of -ence nouns are feminine
In context
Ça ne fait pas de différence pour moi.
It makes no difference to me.
Un uniforme élimine-t-il les différences de classes sociales ?
Does a uniform eliminate class difference?
Quelle est la différence entre ceci et cela ?
What is the difference between this and that?